“The methanolic extract, the butanol and aqueous fractions possess sedative activity while the ethylacetate fraction possesses stimulant property. Flumazenil (2mg/kg, i.p.) abolished the effects of both methanolic extract and the butanol fraction on rearing, locomotion, pentobarbitone sleep and anxiety model. Naltrexone (2.5 mg/kg, i.p.) reversed the inhibition of rearing, locomotion and prolongation of pentobarbitone sleep due to the aqueous fraction of the extract. The butanol and aqueous fractions, but not the methanol extract showed indices of open arm avoidance consistent with anti-anxiety effect. “The ethylacetate fraction however increased both rearing and locomotion and decreased pentobarbitone sleeping time. The methanolic extract, the butanol and the aqueous fractions inhibited rearing and spontaneous locomotion but prolonged pentobarbitone induced sleep. LD50 was calculated for the extract and the fractions after the intraperitoneal route of administration using the Locke method.
NATURAL INSOMNIA CURES PLUS
“The anti-anxiety effect (methanol 2.5–5.0 butanol 5.0 aqueous 20.0 ethylacetate 25.0 mg/kg, i.p.) was assessed using an elevated plus maze.
Sedation was assessed as reduced novelty-induced rearing (NIR), reduced spontaneous locomotor activity (SLA) and increased pentobarbitone-induced sleeping time (PIST) in mice.
The methanolic extract (5–50 mg/kg, i.p.) as well as the ethylacetate (10–50 mg/kg, i.p.), butanol and aqueous fractions (5–50 mg/kg, i.p.) of the extract were examined. “The sedative and anxiolytic effects of the extracts of the leaves of Stachytarpheta cayennensis were examined in this study. The investigations sought scientific evidence for the ethno medicinal use of the leaves for the management of insomnia and anxiety as well as the neural mechanisms for the activities. The researchers write: “The leaves are used ethno medicinally in Nigeria and other parts of the world for insomnia and anxiety among other uses. The study titled “Sedative and Anxiolytic Effects of the Extracts of the Leaves of Stachytarpheta Cayennensis in Mice” was published in African Journal Traditional Complementary Alternative Medicine. They have also scientifically confirmed the rationale for the ethno medicinal use of the leaves for the management of insomnia and anxiety. Nigerian researchers have found how opioid receptors enhance sedative activity of the leaves of Stachytarpheta cayennensis. In Nigeria, it is called tsárkíyárkúúsùù in Hausa, àgógó ìgún in Yoruba. CHUKWUMA MUANYA writes.ĬOMMONLY called snakeweed and rat tail, Stachytarpheta cayennensis, belongs to the plant family Verbenaceae. Top on the list is a local plant, Stachytarpheta cayennensis. Researchers have identified natural remedies for sleeplessness also known as insomnia. Have you murdered sleep? When was the last time you had a good night rest? Have you been living on sleeping pills or rather sedatives with little or no success? Not to worry.
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